Research areas

In the field of antimicrobial peptides, we are working on the following main areas:

• De novo sequencing
• Identification of bacterial target proteins
• Development of derived compounds for the treatment of resistant Gram-negative bacteria
• Interaction with membranes

With respect to the focus on post-translational modifications, we work on functional, structural and analytical aspects:

• enzymatic modifications: Phosphorylation, methylation, glycosylation
• non-enzymatic modifications: oxidation, glycation, glycoxidation

In the focus area of proteomics, we were able to establish both gel- and LC-MS-based methods in the various projects:

• Luminescence techniques: time-resolved fluorescence, multiplexing, diagnostics
• Highly sensitive diagnostics: fluorescence techniques, immuno-PCR
• Separation methods: (multidimensional) chromatography, electrophoresis and capillary electrophoresis

The following peptide synthesis strategies are established in our group:

• Modified Peptides
• Peptide active ingredients
• Peptide/peptide and peptide/protein ligation