Our research focus is in the field of bioanalytics and deals with protein analytical issues.

Elektronenmikroskopie Aufnahme von 3 Escherichia coli Zellen nach Behandlung mit antimikrobiellen Peptid Api137
Elektronenmikroskopische Aufnahme von E. coli Zellen nach Behandlung mit antimikrobiellen Peptid, Foto: Universität Leipzig, BBZ, Bioanalytik

In the primarily biochemically and medically oriented research projects, targeted bioanalytical topics are addressed, new technologies developed and methods optimized.

Agarplatte mit E. coli Bakterienkolonien
Agarkultur von E. coli Bakterien, Foto: Universität Leipzig, BBZ, Bioanalytik

In the field of antimicrobial peptides, we are working on the following main areas:

  • De novo sequencing
  • Identification of bacterial target proteins
  • Development of derived compounds for the treatment of resistant Gram-negative bacteria
  • Interaction with membranes
Mikroskopische Aufnahme eines gefärbten Hirnschnitt zur Detektion modifizierter Proteinvarianten
Gefärbter Hirnschnitt zur Detektion modifizierter Proteinvarianten, Foto:Universität Leipzig, BBZ, Bioanalytik

With respect to the focus on post-translational modifications, we work on functional, structural and analytical aspects:

  • enzymatic modifications: Phosphorylation, methylation, glycosylation
  • non-enzymatic modifications: oxidation, glycation, glycoxidation
Gewebeschnitt eines Mausgehirns auf Träger für MALDI Imaging
Gewebeschnitt auf Träger für MALDI Imaging, Foto: Universität Leipzig, BBZ, Bioanalytik

In the focus area of proteomics, we were able to establish both gel- and LC-MS-based methods in the various projects:

  • Luminescence techniques: time-resolved fluorescence, multiplexing, diagnostics
  • Highly sensitive diagnostics: fluorescence techniques, immuno-PCR
  • Separation methods: (multidimensional) chromatography, electrophoresis and capillary electrophoresis
Robot-assisted peptide synthesis.
Roboterunterstützte Peptidsynthese, Foto: Universität Leipzig, BBZ, Bioanalytik

The following peptide synthesis strategies are established in our group:

  • Modified Peptides
  • Peptide active ingredients
  • Peptide/peptide and peptide/protein ligation

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