Prof. Dr. Norbert Sträter

Prof. Dr. Norbert Sträter

Professor

None
Biotechnologisch-Biomedizinisches Zentrum
Deutscher Platz 5, Room 1.110
04103 Leipzig

Phone: +49 341 97-31311
Fax: +49 341 97-31319

Abstract

My research is focused on molecular recognition in biocatalysis, enzyme inhibition and signal transduction. We study the interaction of ligands and proteins via X-ray crystallography, binding assays, kinetics as well as biophysical and spectroscopic techniques. A main aim is to characterize the molecular principles of interaction leading to specificity, catalysis as well as conformational changes such as domain motions. This information is used to understand the mode of action of enzymes, receptors and other proteins and also to apply it to structure-based rational design of novel biocatalysts and pharmacologically relevant protein inhibitors. In addition to experimental methods, computational tools are a key method to rationalize structure-function relationships as well as for enzyme or inhibitor design.


Professional career

  • 06/1991 - 03/1994
    Doctoral studies with Prof. Bernt Krebs at University of Münster, GermanyDr. rer. nat, University of Münster (“Crystal structure analysis of a purple acid phosphatase”
  • 04/1994 - 03/1997
    Postdoc with Prof. William N. Lipscomb, Harvard University, Cambridge, USA.Topic: Structural studies on chorismate mutase and leucine aminopeptidase
  • 04/1997 - 04/2002
    Habilitation (“Dinuclear Metallohydrolases”) and venia legendi in Biochemistry, Freie Universität Berlin, Advisor: Prof. Wolfram SaengerTopic: Dinuclear metallohydrolases
  • since 05/2002
    Full professor (C4) for Structure Analysis of Biopolymers, Leipzig University
  • 10/2006 - 10/2016
    Director of the Institute of Bioanalytical Chemistry, Leipzig University

Education

  • 10/1986 - 05/1991
    Chemistry (Diploma) studies at University of Münster, Germany

Panel Memberships

  • 06/2002 - 06/2009
    Mitglied im Vorstand des Biotechnologisch-Biomedizinischen Zentrums
  • 03/2009 - 03/2015
    Member of the executive board of the German Crystallographic Association
  • since 06/2012
    Member of the Commission on Biological Macromolecules of the International Union of Crystallography
  • since 06/2012
    Member of editorial board (co-editor) of Acta Crystallographica Section F
  • 10/2012 - 10/2016
    Head of the administrative panel for doctoral studies of the Faculty of Chemistry and Mineralogy
  • 10/2013 - 10/2016
    Vice Dean of the Faculty of Chemistry and Mineralogy
  • 10/2016 - 10/2019
    Dean of the Faculty of Chemistry and Mineralogy
  • Molecular recognition in substrate and ligand specificity
  • Protein structure analysis, X-ray crystallography
  • Extracellular signalling, Purinergic signalling
  • Enzyme mechanism and biocatalysis, Dinuclear metallohydrolases
  • Structure based drug design