Prof. Dr. Mareike Zink

Prof. Dr. Mareike Zink

Research Fellow

Physik weicher Materie/Zellbiophysik
Institutsgebäude
Linnéstraße 5, Room 313
04103 Leipzig

Phone: +49 341 97-32573
Fax: +49 341 97-32479

Abstract

The research of Mareike Zink and her group is focused on the understanding the physics of cells and tissues for biomedical applications: How do topological cues influence cell adhesion and why is the interaction of cells with surfaces important for cell and tissue organization? Answers to these questions are the aim of our research within the Biotechnology and Biomedical Group.

By employing various microscopy techniques in combination with different force spectroscopy methods, as well as self-developed setups, the research group aim to get more insight into cell-surface interaction forces to correlate physical properties with biological aspects such as tissue structure and function. Moreover, the group use tissues from slaughter houses to study the mechanical properties of complex neuronal tissues such as the retina for a better understanding of eye diseases. By showing how nanostructured surfaces promote tissue adhesion and long-term survival for organotypic culture of adult tissue, the study also paves new ways in replacing animal experiments by ex vivo culture models. Additionally, Mareike Zink investigate tissue mechanics and their variations during development from an embryo to an adult to understand how structural changes (e.g. within the extracellular matrix) influence organ function or promote tumor growth.

  • MUDIplex: Entwicklung einer Multiwell-Ultra High Dense-Mikroelektroden- und Oszillatorenarray-Multiplexer-Plattform für räumlich-zeitlich hochaufgelöstes Monitoring zellulärer Biomechanik im Live-Modus
    Robitzki, Andrea
    Duration: 02/2018 - 12/2020
    Funded by: SMWK Staatsministerium für Wissenschaft und Kunst
    Involved organisational units of Leipzig University: Molekularbiologisch-biochemische Prozesstechnik; Peter-Debye-Institut für Physik der weichen Materie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
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  • Orthotopic tumor transplantation experiments to verify the theory of ontogenetic cancer fields
    Aktas, Bahriye
    Duration: 01/2017 - ongoing
    Funded by: Haushaltsmittel (TG51, Overhead); Stiftungen Inland
    Involved organisational units of Leipzig University: Klinik und Poliklinik für Frauenheilkunde
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  • Plasmaunterstützte Funktionalisierung magnetischer Kern-Schale-Nanopartikel mit Biomolekülen für die medizinische Diagnostik (BIOCOAT)
    Zink, Mareike
    Duration: 02/2016 - 12/2018
    Funded by: Sächsische Wirtschaft
    Involved organisational units of Leipzig University: Physik weicher Materie/Zellbiophysik; Wechselwirkung von Oberflächen mit biologischen Zellen und Geweben; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
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  • Organotypische Langzeitkultivierung von adultem Augengewebe zur Erforschung von Krankheiten und Wirkstofen in vitro - EYECULTURE
    Zink, Mareike
    Duration: 08/2015 - 07/2022
    Funded by: BMBF Bundesministerium für Bildung und Forschung
    Involved organisational units of Leipzig University: Physik weicher Materie/Zellbiophysik; Wechselwirkung von Oberflächen mit biologischen Zellen und Geweben; Biotechnologisch-Biomedizinisches Zentrum (BBZ); Sächsischer Inkubator für klinische Translation (SIKT)
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  • Dynamic-mechanical cell manipulation and characterization using magnetostrain
    Zink, Mareike
    Duration: 07/2013 - 09/2021
    Funded by: DFG Deutsche Forschungsgemeinschaft
    Involved organisational units of Leipzig University: Physik weicher Materie/Zellbiophysik; Wechselwirkung von Oberflächen mit biologischen Zellen und Geweben; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
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more projects

  • Kupferer, A.; Mayr, S. G.; Zink, M.
    Influence of Topological Cues on Fibronectin Adsorption and Contact Guidance of Fibroblasts on Microgrooved Titanium
    ACS Applied Bio Materials. 2019. pp. 1066-1077
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  • Kallendrusch, S.; Merz, F.; Bechmann, I.; Mayr, S. G.; Zink, M.
    Long-Term Tissue Culture of Adult Brain and Spleen Slices on Nanostructured Scaffolds
    Advanced Healthcare Materials. 2017. 6 (9).
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  • Juncheed, K.; Kohlstrunk, B.; Friebe, S.; Dallacasagrande, V.; Maurer, P.; Reichenbach, A.; Mayr, S. G.; Zink, M.
    Employing Nanostructured Scaffolds to Investigate the Mechanical Properties of Adult Mammalian Retinae Under Tension
    International journal of molecular sciences. 2020. 21 (11).
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  • Abend, A.; Steele, C.; Schmidt, S.; Frank, R.; Jahnke, H.-G.; Zink, M.
    Neuronal and glial cell co-culture organization and impedance spectroscopy on nanocolumnar TiN films for lab-on-a-chip devices
    Biomaterials Science. 2022.
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  • Naumann, J.; Koppe, N.; Thome, U.; Laube, M.; Zink, M.
    Mechanical properties of the premature lung: from tissue deformation under load to mechanosensitivity of alveolar cells
    Frontiers in Bioengineering and Biotechnology. 2022.
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more publications

  • Experimental Physics and mathematical methods EP2

    Electrodynamics (Higher Education)

    Modul 12-PHY-L-EP2-A