Die Forschungsergebnisse in den von unserer Mitarbeiterinnen und Mitarbeitern bearbeiteten Projekte werden in internationalen peer-review Journalen veröffentlicht und sind in der Forschungsgemeinschaft beachtet und zitiert.

zur Vergrößerungsansicht des Bildes: Foto: Colourbox
Publikationen. Foto: Colourbox

267. Lauer, S. M., Reepmeyer, M., Berendes, O., Klepacki, D., Gasse, J., Gabrielli, S., Grubmüller, H., Bock , L. V., Krizsan, A., Nikolay, R., Spahn, C. M. T., Hoffmann, R. (2024) Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88. Nature Commun., 15:3945, 1-19. https://doi.org/10.1038/s41467-024-48027-4

266. Rottmayer, K., Schwarze, M., Jassoy, C., Hoffmann, R., Loeffler-Wirth, H., Lehmann, C. (2024) Potential of a bead-based multiplex assay for SARS-CoV-2 antibody detection. Biology 13, 273, 1-15. https://doi.org/10.3390/biology13040273

265. Schwarze, M., Volke, D., Rojas Echeverri, J.C., Schick, R., Lakowa, N., Grünewald, T., Wolf, J., Borte, S., Scholz, M., Krizsan, A., Hoffmann, R. (2024) Influence of mutations and N-glycosylation sites in the receptor-binding domain (RBD) and the membrane protein of SARS-CoV-2 variants of concern on antibody binding in ELISA. Biology, 13, 207, 1-21. https://doi.org/10.3390/biology13040207

264. De Spiegeleer, A. Descamps, A., Wynendaele, E., Naumovski, P., Crombez, L., Planas, M., Feliu, L., Knappe, D., Mouly, V., Bigot, A., Bielza, R., Hoffmann, R., Van Den Noortgate, N., Elewaut, D., De Spiegeleer, B. (2024) Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting. Biochim. Biophys. Acta Mol. Basis Dis. 1870(4): 167094. https://doi.org/10.1016/j.bbadis.2024.167094

263. Jentsch, M.-C., Lübke, S., Schrödl, W., Volke, D., Krizsan, A., Hoffmann, R., Kaiser-Thom, S., Gerber, V., Marti, E., Wagner B., Schnabel, C.-L. (2024) Immunoproteomics enables broad identification of new Aspergillus fumigatus antigens in severe equine asthma. Front. Immunol. 15:1347164. https://doi.org/10.3389/fimmu.2024.1347164

262. Selg, C., Grell, T., Brakel, A., Andrews, P. C., Hoffmann, R., Hey-Hawkins, E. (2024) Fusing Bismuth and Mercaptocarboranes: Design and Biological Evaluation of Low-Toxicity Antimicrobial Thiolato Complexes. ChemPlusChem 23:e202300759, 1-9. https://doi.org/10.1002/cplu.202300759

261. Brakel, A. Grochow, T., Fritsche, S., Knappe, D., Krizsan, A., Fietz, S.A., Alber, G., Hoffmann, R., Müller, U. (2024) Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans. Front. Microbiol. 14:1328890. https://doi.org/10.3389/fmicb.2023.1328890

260. Schnabel, C. L., Jentsch, M.-C., Lübke, S., Kaiser-Thom, S., Gerber, V., Vrtala, S., Huang, H.-J., Rhyner, C., Wagner, B., Hoffmann, R., and Volke, D. (2023) Immunoproteomics reveal increased serum IgG3/5 binding to Dermatophagoides -and yeast protein antigens in severe equine asthma in a preliminary study. Front Immunol. 14:1293684. https://doi.org/10.3389/fimmu.2023.1293684

259. Mötzing, M., Blüher, M., Grunwald, T., Hoffmann, R. (2023) Immunological quantitation of the glycation site lysine-414 in serum albumin in human serum samples by indirect ELISA using highly specific monoclonal antibodies. ChemBioChem, e202300550, 1-7. https://doi.org/10.1002/cbic.202300550

258. Mangano, K., Klepacki, D., Ohanmu, I., Baliga, C., Huang, W., Brakel, A., Krizsan, A., Polikanov, Y.S., Hoffmann, R., Vázquez-Laslop, N., Mankin, A.S. (2023) Inhibition of translation termination by the antimicrobial peptide drosocin. Nat. Chem. Biol. 19: 1082-1090. https://doi.org/10.1038/s41589-023-01300-x

257. Mohammed, G.K., Böttger, R., Krizsan, A., Volke, D., Mötzing, M., Li, S.-D., Knappe, D., Hoffmann, R. (2023) In Vitro Properties and Pharmacokinetics of Temporarily PEGylated Onc72 Prodrugs. Adv. Healthcare Mater. 2202368, 1-10. https://doi.org/10.1002/adhm.202202368

256. Su, P., Warneke, Z., Volke, D., Espenship, M.F., Hu, H., Kawa, S., Kirakci, K., Hoffmann, R., Laskin, J., Wiebeler, C., Warneke, J. (2023) Gas Phase Reactivity of [Mo6X14]2− Dianions (X = Cl − I). J. Am. Soc. Mass Spectrom. doi.org/10.1021/jasms.2c00243

255. Schwarze, M., Luo, J., Brakel, A., Krizsan, A., Lakowa, N., Grünewald, T., Lehmann, C., Wolf, J., Borte, S., Milkovska-Stamenova, S., Gabert, J., Scholz, M., Hoffmann, R. (2022) Evaluation of S- and M-proteins expressed in Escherichia coli and HEK cells for serological detection of antibodies in response to SARS-CoV-2 infections and mRNA-based vaccinations. Pathogens, 11: 1515, 1-16. DOI: 10.3390/pathogens11121515

254. Berg, A., Gräber, M., Schmutzler, S., Hoffmann, R., Berg, T. (2022). A high-throughput fluorescence polarization-based assay for the SH2 domain of STAT4. Methods Protoc. 5: 93, 1-11. https://doi.org/10.3390/mps5060093

253. Luo, J., Klett, J., Gabert, J., Lipp, T., Karbach, J., Jäger, E., Borte, S., Hoffmann, R., Milkovska-Stamenova, S. (2022) A quantitative ELISA to detect anti-SARS-CoV-2 spike IgG antibodies in infected patients and vaccinated individuals. Microorganisms. 10: 1812, 1-15. DOI: 10.3390/microorganisms10091812

252. De Spiegeleer, A., Wynendaele, E., Descamps, A., Debunne, N., Braeckman, B., De Mey, M., Coudenys, J., Crombez, L., Verbeke, F.,; Janssens, Y., Janky, R., Goossens, E., Vlaeminck, C., Duchi, D., Andries, V., Dumas, E., Petrovic, M., Van De Wiele, T., Knappe, D., Hoffmann, R., Mouly, V., Bigot, A., Vereecke, L., Van Immerseel, F., Van Den Noortgate, N., De Spiegeleer, B., Elewaut, D. (2022) The bacterial Quorum Sensing Peptide iAM373 is a novel inducer of sarcopenia. Clin. Transl. Med. 12:e1053, 1-5. DOI: 10.1002/ctm2.1053 

251. Brauer, J., Mötzing, M., Gröst, C., Hoffmann, R., Berg, T. (2022) Templated generation of a Bcl-xL inhibitor by isomer-free SPAAC based on azacyclonon-5-yne. Chem. Eur. J. 28,   e202202259(1 of 7) https://doi.org/10.1002/chem.202202259

250. Schmutzler, S., Hoffmann, R. (2022) Chromatographic separation of glycated peptide isomers derived from glucose and fructose. Anal. Bioanal. Chem. 414: 6801-6812 DOI: 10.1007/s00216-022-04243-9

249. Echeverri, J.C.R., Volke, D., Milkovska‐Stamenova, S., Hoffmann, R. (2022) Evaluating Peptide Fragment Ion Detection Using Traveling Wave Ion Mobility Spectrometry with Signal-Enhanced MSE (SEMSE). Anal. Chem. 94: 10930-10941. https://doi.org/10.1021/acs.analchem.2c00461

248. Ludwig, T., Hoffmann, R., Krizsan, A. (2022) Construction and characterization of T7 bacteriophages harboring. Curr. Issues Mol. Biol. 2, 2554-2568. https://doi.org/10.3390/cimb44060174

247. Schwarze, M., Krizsan, A., Brakel, A., Pohl, F., Volke, D., Hoffmann, R. (2022) Cross-reactivity of IgG antibodies and virus neutralization in mRNA vaccinated people against wild type SARS-CoV-2 and the five most common SARS-CoV-2 variants of concern. Front. Immunol. 13: 915034, 1-11. https://doi.org/10.3389/fimmu.2022.915034

246. Schmutzler, S., Wölk, M., Hoffmann R. (2022) Differentiation and Quantitation of Coeluting Isomeric Amadori and Heyns Peptides Using Sugar-Specific Fragment Ion Ratios. Anal Chem. 94: 7909-7917. https://doi.org/10.1021/acs.analchem.2c00681

245. Marisa, I., Asnicar, D., Matozzo, V., Parolini, M., Brianese, N., Fedorova, M., Hoffmann, R., Sheehan, D., Marin, M. G. (2022) Zinc oxide, titanium dioxide and C60 fullerene nanoparticles, alone and in mixture, differently affect biomarker responses and proteome in the clam Ruditapes philippinarum. Sci. Total Environ. 838:155873. https://doi.org/10.1016/j.scitotenv.2022.155873

244. Böttger, R., Chao, P.H., AL Fayez, N., Pauli, G., Nguyen, A., Hohenwarter, L., Bilal, N., Mohammed, G., Knappe, D., Hoffmann, R., Li, S.-D. (2022) Simultaneous Chromatographic Quantitation of Drug Substance and Excipients in Nano-Formulations Using a Combination of Evaporative Light Scattering and Absorbance Detectors. Mol. Pharmaceutics, 6:19, 1882-91. https://doi.org/10.1021/acs.molpharmaceut.2c00021

243. Wynendaele, E., Debunne, N., Janssens, Y., De Spiegeleer, A., Verbeke, F., Tack, L., Van Welden, S., Goossens, E., Knappe, D., Hoffmann, R., Van de Wiele, C., Laukens, D., Van Eenoo, R., Vereecke, L., Van Immerseel, F., De Wever, O., De Spiegeleer, B. (2022) The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: a new factor in the host-microbiome interaction. BMC Biology, 20:151, 1-16. https://doi.org/10.1186/s12915-022-01317-z

242. Wölk, M., Milkovska-Stamenova, S., Fedorova, M., Hoffmann, R. (2022) Variations in the milk lipidomes of two dairy cow herds fed hay- or silage-based diets over a full year. Food Chem.  390:133091, 1- DOI: 10.1016/j.foodchem.2022.133091

241. Goss, R., Volke, D., Werner, L.E., Kunz, R., Kansy, M., Hoffmann, R., Wilhelm, C. (2022) Isolation of fucoxanthin chlorophyll protein complexes of the centric diatom Thalassiosira pseudonana associated with the xanthophyll cycle enzyme diadinoxanthin de-epoxidase. IUBMB Life, DOI: 10.1002/iub.2650 

240. Ludwig, T., Krizsan, A., Mohammed, G.K., Hoffmann, R. (2022) Antimicrobial activity, 70S ribosome binding, and bacterial uptake of apidaecin derivative Api805. Antibiotics, 11, 430, 1-13. doi: 10.3390/antibiotics11040430

239. Brakel, A., Krizsan, A., Itzenga, R., Kraus, C., Otvos, L., Hoffmann, R. (2022) Influence of substitutions in the binding motif of proline-rich antimicrobial peptide ARV-1502 on 70S ribosome binding and antimicrobial activity. Int. J. Mol. Sci. 23: 3150, 1-15. https://doi.org/10.3390/ijms23063150

238. Luo, J., Brakel, A., Krizsan, A., Ludwig, T., Mötzing, M., Volke, D., Lakowa, N., Grünewald, T., Lehmann, C., Wolf, J., Borte, S., Milkovska-Stamenova, S., Gabert, J., Fingas, F., Scholz, M., Hoffmann, R. (2022) Sensitive and specific serological ELISA for the detection of SARS-CoV-2 infections. Virol. J. 19: 50, 1-10. doi: 10.1186/s12985-022-01768-4

237. Brakel, A., Kolano, L., Kraus, C. N., Otvos, L. Jr., Hoffmann, R. (2022) Functional Effects of ARV-1502 Analogs Against Bacterial Hsp70 and Implications for Antimicrobial Activity. Front Chem. 10:798006. https://doi.org/10.3389/fchem.2022.798006


236. Kolano, L., Knappe, D., Berg, A., Berg, T., Hoffmann, R. (2021) Effect of Amino Acid Substitutions on 70S Ribosomal Binding, Cellular Uptake, and Antimicrobial Activity of Oncocin Onc112. Chembiochem. 23(5): https://doi.org/10.1002/cbic.202100609

235. Milkovska-Stamenova, S., Wölk, M., Hoffmann, R. (2021) Evaluation of sample preparation strategies for human milk and plasma proteomics. Molecules. 26(22): 6816. https://doi.org/10.3390/molecules26226816

234. Wölk, M., Gebauer, C., Hoffmann, R., Milkovska-Stamenova, S. (2021) Analysis of the endogenous peptidomes of different infant formula types and human milk. Foods 10(11): 2579. https://doi.org/10.3390/foods10112579

233. Hochmuth, L., Körner, C., Ott, O., Volke, D., Blagotinšek Cokan, K., Juvan, P., Brosch, M., Hofmann, U., Hoffmann, R., Rozman, D., Berg, T., Matz-Soja, M. (2021) Sex-dependent dynamics of metabolism in primary mouse Hepatocytes. Arch. Toxicol., 95: 3001–3013. PMID: 34241659

232. Gressler,A.E., Volke, D., Firacative, C., Schnabel, C.L., Müller, U., Krizsan, A., Schulze-Richter, B., Brock, M., Brombacher, F., Escandon, P., Hoffmann R., Alber G. (2021) Identification of disease-associated cryptococcal proteins reactive with serum IgG from cryptococcal meningitis patients. Front. Immunol. 12: 709695. PMID: 34367172

231. Schmutzler, S., Knappe, D., Marx, A., Hoffmann, R. (2021) Solid‑phase synthesis of d‑fructose‑derived Heyns peptides utilizing Nα‑Fmoc‑Lysin[Nε‑(2‑deoxy-d-glucos-2-yl),Nε‑Boc]-OH as building block. Amino Acids, 53: 881-891. https://doi.org/10.1007/s00726-021-02989-7

230. Echeverri, J.C.R., Milkovska‐Stamenova, S., Hoffmann, R. (2021) A Workflow towards the Reproducible Identification and Quantitation of Protein Carbonylation Sites in Human Plasma. Antioxidants, 10: 369, 1-22. PMID: 33804523

229. Sinatra, L., Kolano, L., Icker, M., Fritzsche, S.R., Volke, D., Gockel, I., Thieme, R., Hoffmann, R., Hansen, F.K. (2021) Hybrid Peptides Based on α-Aminoxy Acids as Antimicrobial and Anticancer Foldamers. ChemPlusChem, in press.

228. Krieger, A.K., Knappe, D. Öhlmann, S., Mayer, L., Eder, I.B., Köller, G., Hoffmann, R., Rieckmann, K., Baums, C.G. (2021) Proline-rich antimicrobial peptide Api137 is bactericidal in porcine blood infected ex vivo with a porcine or human Klebsiella pneumoniae strain. J. Glob. Antimicrob. Resist. 24: 127-135. PMID: 33373733

227. Wölk, M., Milkovska-Stamenova, S., Hoffmann, R. (2020) Comprehensive profiling of the native and modified peptidomes of raw bovine milk and processed milk products. Foods. 9:1841. PMID: 33321979

226. Wölk, M., Schröter, T., Hoffmann, R., Milkovska-Stamenova, S. (2020) Profiling of low molecular weight carbonyls and protein modifications in flavored milk. Antioxidants. 9:1169. PMID: 33238606

225. Kähl, S., Volke, D., Fornefett, J., Fingas, F., Klose, K., Benga, L., Grunwald, T., Ulrich, R., Hoffmann, R., Baums, C.G. (2020) Identification of a large repetitive RTX immunogen in a highly virulent Rodentibacter heylii strain. Microbes Infect. S1286-4579(20): 30185-4. PMID: 33164813

224. Kansy, M., Volke, D., Sturm, L., Wilhelm, C., Hoffmann, R., Goss, R. (2020) Pre-purification of diatom pigment protein complexes provides insight into the heterogeneity of FCP complexes. BMC Plant Biology. 20: 456. PMID: 33023504

223. Wölk, M., Milkovska-Stamenova, S., Schröter, T., Hoffmann, R. (2020) Influence of seasonal variation and processing on protein glycation and oxidation in regular and hay milk. Food Chem. 337:127690. PMID: 32795853

222. Kolano, L, Knappe, D, Volke, D, Sträter, N, Hoffmann, R. (2020) Ribosomal Target-Binding Sites of Antimicrobial Peptides Api137 and Onc112 Are Conserved Among Pathogens Providing New Lead Structures to Develop Novel Broad-Spectrum Antibiotics. ChemBioChem. 21:2628-2634. PMID: 32293093

221. Brakel, A., Volke, D., Kraus, C.N., Otvos, L., Hoffmann, R. (2019) Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs. Frontiers in Chemistry 7:753. PMID: 31799234

220. Knappe, D., Schmidt, R., Adermann, K., Hoffmann, R. (2019) Continuous subcutaneous delivery of proline-rich antimicrobial peptide Api137 provides superior efficacy to intravenous administration in a mouse infection model. Front. Microbiol. 10:2283. PMID: 31632382

219. Fingas, F., Volke, D., Hassert, R., Fornefett, J., Funk, S., Baums, C.G., Hoffmann R. (2019) Sensitive and immunogen-specific serological detection of Rodentibacter pneumotropicus infections in mice. BMC Microbiology 19: 43. PMID: 30777007

218. Milkovska-Stamenova, S., Hoffmann, R. (2019) Diversity of advanced glycation endproducts in the bovine milk proteome. Amino Acids 51: 891-901. PMID: 30963298

217. Matamoros, M., Kim, A., Peñuelas, M., Ihling, C., Griesser, E., Hoffmann, R., Fedorova, M., Frolov, A., Becana. M. (2018) Protein Carbonylation and Glycation in Legume Nodules. Plant Physiol. 177: 1510-1528. PMID: 29970413


216. Milkovska-Stamenova, S., Krieg, L., Hoffmann, R. (2018) Products of early and advanced glycation in the soy milk proteome. Mol. Nutr. Food Res. 15: e1800725. PMID: 30430721

215. Otvos, L., Ostorhazi, E., Hoffmann, R., Herth, N., Wade, J.D., Kraus, C.N. (2018) Advantage of a narrow spectrum host defense (antimicrobial) peptide over a broad spectrum analog in preclinical drug development. Front. Chem. 6:359 1-11. PMID: 30186829

214. Fingas, F., Rückner, A., Heenemann, K., Volke, D., Sieg, M., Bielefeldt, P., Grunwald, T. Vahlenkamp, T.W., Hassert, R., Hoffmann R. (2018) Highly sensitive ELISA for the serological detection of murine rotavirus EDIM based on its major immunogen VP6. J. Virol. Meth. 262: 72-78. PMID: 30144945

213. Fingas, F. Volke, D., Bielefeldt, P. Hassert, R., Hoffmann, R. (2018) Detection of mammalian orthoreovirus type-3 (Reo-3) infections in mice based on serotype-specific hemagglutination protein sigma-1. Virol. J. 15: 114. PMID: 30049287

212. Spiller, S., Blüher, M., Hoffmann, R. (2018) Plasma levels of free fatty acids correlate with type 2 diabetes mellitus. Diabetes, Obesity and Metabolism. 20: 2661-9. PMID: 29943387

211. Lis, C., Rubner, S., Gröst, C., Hoffmann, R., Knappe, D., Berg, T. (2018) iSPAAC: isomer-free generation of a Bcl-xL-inhibitor in living cells. Chemistry 24: 13762-13766. PMID: 29917279

210. Böttger, R., Knappe, D., Hoffmann, R. (2018) PEGylated prodrugs of antidiabetic peptides amylin and GLP-1. J. Contr. Rel. 2;292: 58-66. PMID: 29729352

209. Spiller, S., Li, Y., Blüher, M., Welch, L., Hoffmann, R. (2018) Diagnostic accuracy of protein glycation sites in long-term controlled patients with type 2 diabetes mellitus and their prognostic potential for early diagnosis. Pharmaceuticals, 11(38): 1-13. PMID: 29710851

208. Sultan, C.S., Saackel, A. Stank, A., Fleming, T., Fedorova, M., Hoffmann, R., Wade, R.C., Hecker, M., Wagner, A.H. (2018) Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biol. 16: 113-122. PMID: 29499564

207. Martin, L.L., Kubeil, C., Piantavigna, S., Tikkoo, T., Gray, N.P., John, T., Calabrese, A.N., Liu, Y., Hong, , Y., Hossain, A., Patil, N., Abel, B., Hoffmann, R., Carver, J.A., Bowie, J.H. (2018) Amyloid Aggregation and Membrane Activity of the Antimicrobial Peptide Uperin 3.5. Peptide Science, 110: e24052 1-9. https://doi.org/10.1002/pep2.24052

206. Almaaytah, A., Al-Qaoud, M., Mohammed, G. K., Abualhaijaa, A., Knappe, D., Hoffmann, R., Al-Balas, Q. (2018) Antimicrobial and antibiofilm activity of UP-5, an ultrashort antimicrobial peptide designed using only arginine and biphenylalanine. Pharmaceuticals, 11(3): 1-18. PMID: 29301331

205. Kurz, S., Thieme, R., Amberg, R., Groth, M., Jahnke, H.G., Pieroh, P., Horn, L.C., Kolb, M., Huse, K., Platzer, M., Volke, D., Dehghani, F., Buzdin, A., Engel, K., Robitzki, A., Hoffmann, R., Gockel, I., Birkenmeier, G. (2017) The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat. PLoS One. 12(12):e0189514. PMID: 29579117

204. Holfeld, L., Knappe, D., Hoffmann, R. (2018) Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae. J. Antimicrob. Chemother. 73: 933-941 PMID: 29309652

203. Ni, Z., Angelidou, G., Lange, M., Hoffmann, R. & Fedorova, M. (2017) LPPtiger software for lipidome-specific prediction and identification of oxidized phospholipids from LC-MS datasets. Sci Rep. 7:15138. PMID: 29123162

202. Schmidt, R., Yonghong, D., Hoffmann, R. (2018) Phospholipid composition of the outer membrane of Escherichia coli influences its susceptibility against antimicrobial peptide apidaecin 1b. Diagnost. Microbiol. Infect. Dis., 90: 316-323. PMID: 29329756

201. Ni, Z., Angelidou, G., Lange, M., Hoffmann, R. & Fedorova, M. (2017) LipidHunter identifies phospholipids by high-throughput processing of LC-MS and shotgun lipidomics datasets. Anal. Chem. 89(17): 8800–8807. PMID: 28753264

200. Holfeld, L., Hoffmann, R. & Knappe, D. (2017) Correlating uptake and activity of proline-rich antimicrobial peptides in Escherichia coli.  Anal. Bioanal. Chem., 409(23): 5581-5592. PMID: 28717895.

199. Böttger, R., Hoffmann, R. & Knappe, D. (2017) Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum. PLoS ONE 12(6): e0178943. PMID: 28575099

198. Spiller, S. Li, Y. Welch, L., Blüher, M. & Hoffmann, R. (2017) Glycated lysine-141 in haptoglobin improves the diagnostic accuracy for type 2 diabetes mellitus in combination with glycated hemoglobin HbA1c and fasting plasma glucose. Clin. Proteom. 14:10. PMID: 28360826

197. Schmidt, R., Knappe, D., Wende, E., Ostorhazi, E. & Hoffmann, R. (2017) In vivo efficacy and pharmacokinetics of optimized apidaecin analogs. Front. Chem. 5: 15. PMID: 28373972

196. Milkovska-Stamenova, S. & Hoffmann, R. (2017) Protein carbonylation sites in bovine raw milk and processed milk products. Food Chem. 229: 417–424. PMID:  28372194

195. Spiller, S., Frolov, A. & Hoffmann, R. (2017) Quantification of specific glycation sites in human serum albumin as prospective Type 2 diabetes mellitus biomarkers. Prot. Pept. Lett. in press PMID: 28155619

194. Goss, R., Greifenhagen, A., Bergner, J., Volke, D., Hoffmann, R., Wilhelm, C. & Schaller-Laudel, S. (2017) Direct isolation of a functional violaxanthin cycle domain from thylakoid membranes of higher plants. Planta  245: 793-806. PMID: 28025675

193. Milkovska-Stamenova, S. & Hoffmann, R. (2017) Influence of storage and heating on protein glycation levels of processed lactose-free and regular bovine milk products. Food Chem. 221: 489-495. PMID: 27979232

192. Shamova, O.V., Orlov, D.S., Zharkova, M.S., Balandin, S.V, Yamschikova, E.V., Knappe, D., Hoffmann, R., Kokryakov, V.N., & Ovchinnikova T.V. (2016) Minibactenecins ChBac7.Na and ChBac7.Nß-antimicrobial peptides from leukocytes of the goat Capra hircus. Acta Naturae  8: 136-146. PMID: 27795854

191. Knappe, D., Goldbach, T., Hatfield, M.P.D., Palermo, N.Y., Weinert, S., Sträter, N., Hoffmann, R. & Lovas, S. (2016) Proline-rich antimicrobial peptides optimized for binding to Escherichia coli chaperone DnaK. Prot. Pept. Lett. 23(12): 1061-1071. PMID: 27449938

190. Schmidt, R., Krizsan, A., Volke, D., Knappe, D. & Hoffmann, R. (2016) Identification of New Resistance Mechanisms in Escherichia coli against Apidaecin 1b Using Quantitative Gel- and LC−MS-Based Proteomics. J. Prot. Res. 15: 2607-2617. PMID: 27405093

189. Goldbach, T., Knappe, D., Reinsdorf, C., Berg, T. & Hoffmann, R. (2016) Ribosomal binding and antibacterial activity of ethylene glycol-bridged apidaecin Api137 and oncocin Onc112 conjugates. J. Pept. Sci. 22: 592-9. PMID: 27406684

188. Greifenhagen, U., Frolov, A., Blüher, M. & Hoffmann, R. (2016) Site-specific analysis of advanced glycation end-products in plasma proteins of type 2 diabetes mellitus patients. Anal. Bioanal. Chem. 408: 5557-5566. PMID: 27236317

187. Knappe, D., Kabankov, N., Herth, N. & Hoffmann, R. (2016) Insect-derived short proline-rich and murine cathelicidin-related antimicrobial peptides act synergistically on Gram-negative bacteria in vitro. Fut. Med. Chem. 8: 1035-45. PMID: 27285299

186. Bluhm, M.E.C., Schneider, V.A.F., Schäfer, I., Piantavigna, S., Goldbach, T., Knappe, D., Seibel, P., Martin, L.L., Veldhuizen, E.J.A. & Hoffmann, R. (2016) N-terminal Ile-Orn- and Trp-Orn-motif repeats enhance membrane interaction and increase the antimicrobial activity of apidaecins against Pseudomonas aeruginosa. Front. Cell. Dev. Biol. 4: 39. PMID: 27243004

185. Böttger, R., Knappe, D. & Hoffmann, R. (2016) Readily adaptable release kinetics of prodrugs using protease-dependent reversible PEGylation. J. Contr. Rel. 230: 88-94. PMID: 27067364

184. Muranyi, I.S., Volke, D., Hoffmann, R., Eisner, P., Herfellner, T., Brunnbauer, M., Koehler, P., Schweiggert-Weisz, U. (2016). Protein distribution in lupin protein isolates from Lupinus angustifolius L. prepared by various isolation techniques. Food Chem. 207: 6-15. PMID: 27080873

183. Annibal, A., Riemer, R., Jovanovic, O., Westphal, D., Griesser, E., Pohl, E.E., Schiller, J., Hoffmann, R. & Fedorova M. (2016) Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines. Free Radical Biol. Med. 95: 293-307. PMID: 27012418

182. Greifenhagen, U., Frolov, A., Blüher, M. & Hoffmann, R. (2016) Plasma Proteins Modified by Advanced Glycation Endproducts (AGEs) Reveal Site-specific Susceptibilities to Glycemic Control in Patients with Type 2 Diabetes. J. Biol. Chem. 291: 9610-9616. PMID: 26933035

181. Schmidt, R., Ostorhazi, E., Wende, E., Knappe, D. & Hoffmann, R. (2016) Pharmacokinetics and in vivo efficacy of optimized oncocin derivatives. J. Antimicrob. Chemother. 71: 1003-1011.

180. Milkovska-Stamenova S., Hoffmann R. (2016) Hexose-derived glycation sites in processed bovine milk. J. Proteomics  134: 102-111. PMID: 26743206

179. Annibal A., Colombo G., Milzani A., Dalle-Donne I., Fedorova M., Hoffmann R. (2016) Identification of dityrosine cross-linked sites in oxidized human serum albumin. J. Chromatogr. B. 1019: 147-155.

178. Stangner, T., Angioletti-Uberti, S., Knappe, D., Singer, D., Wagner, C., Hoffmann, R. & Kremer, F. (2016) Epitope-mapping of monoclonal antibody HPT-101: a study combining dynamic force spectroscopy, ELISA and molecular dynamics simulations. Phys. Biol. 12: 066018.

177. Scharow, A., Knappe, D., Reindl, W., Hoffmann, R. & Berg, T. (2016) Development of Bifunctional Inhibitors of Polo-Like Kinase 1 with Low-Nanomolar Activities Against the Polo-Box Domain. ChemBioChem 17 (8): 759-767. DOI: 10.1002/cbic.201500535

176. Krizsan, A., Prahl, C. Goldbach, T., Knappe, D. & Hoffmann, R. (2015) Short Proline-Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit. ChemBioChem 16 (16): 2304-8. PMID: 26448548

175. Milic, I., Kipping, M., Hoffmann, R. & Fedorova, M. (2015) Separation and characterization of oxidized isomeric lipid-peptide adducts by ion mobility mass spectrometry. J. Mass Spectrom. 50 (12): 1386-92. PMID: 26634972

174. Bluhm M., Knappe, D. & Hoffmann, R. (2015) Structure-activity relationship study using peptide arrays to optimize Api137 for an increased antimicrobial activity against Pseudomonas aeruginosa . Eur. J. Med. Chem. 103: 574-582.

173. Schaller-Laudel, S., Volke, D., Redlich, M. Kansy, M., Hoffmann, R. , Wilhelm, C. & Goss, R. (2015) The diadinoxanthin diatoxanthin cycle induces structural rearrangements of the isolated FCP antenna complexes of the pennate diatom Phaeodactylum tricornutum. Plant Physiol. Biochem. 96: 364-376. PMID: 26368016

172. Knappe, D., Ruden, S., Langanke, S., Tikkoo, T., Ritzer, J., Mikut, R., Martin, L.L., Hoffmann, R. & Hilpert, K. (2015) Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus . Amino Acids 48 (1): 269-80. PMID: 26334348

171. Milkovska-Stamenova, S. & Hoffmann, R. (2015) Identification and quantification of bovine protein lactosylation sites in different milk products. J. Proteomics S1874-3919 (15): 30075-0. PMID: 26210590

170. Krizsan, A., Knappe, D. & Hoffmann, R. (2015) Influence of yjiL and upstream genes on the antibacterial activity of proline-rich antimicrobial peptides overcoming Escherichia coli resistance induced by the missing SbmA transporter system. Antimicrob. Agents Chemother. 59 (10): 5992-8. PMID: 26169420

169. Volke, D., Krizsan, A., Berthold, N., Knappe, D. & Hoffmann, R. (2015) Identification of Api88 binding partners in Escherichia coli using a photoaffinity-crosslink strategy and label free quantification. J. Prot. Res. 14 (8): 3274-83. PMID: 26196380

168. Holfeld, L., Herth, N., Singer, D., Hoffmann, R., and Knappe, D. (2015) Immunogenicity and pharmacokinetics of short, proline-rich antimicrobial peptides. Future med. Chem. 7 (12): 1581-96. PMID: 26308283

167. Knappe, D., Adermann, K., and Hoffmann, R., (2015) Oncocin Onc72 is efficacious against antibiotic-susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model. Biopolymers . 104 (6): 707-11 . PMID: 25968331

166. Weber, D., Ni, Z., Vetter, D., Hoffmann, R. & Fedorova, M. (2015) Electrochemical oxidation of cholesterol: An easy way to generate numerous oxysterols in short reaction times. Eur. J. Lipid Sci. Technol. 118 (2): 325-331. DOI: 10.1002/ejlt.201500101

165. Greifenhagen, U., Frolov, A. & Hoffmann, R. (2015) Oxidative degradation of Nε-fructosylamine-substituted peptides in heated aqueous systems. Amino acids 47: 1065-76. PMID: 25712730

164. Otvos, L. Jr., Kovalszky, I., Olah, J., Coroniti, R., Knappe, D., Nollmann, F.I., Hoffmann, R., Wade, J.D., Lovas, S. & Surmacz, E. (2015) Optimization of adiponectin-derived peptides for inhibition of cancer cell growth and signaling, Biopolymers 104: 156–166. PMID: 25683126

163. Ebner, J., Arslan, A.A., Fedorova, M., Hoffmann, R., Küçükçetin, A., Pischetsrieder, M. (2015) Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains. J. Proteomics 117: 41-57. PMID: 25613046

162. Greifenhagen, U., Nguyen, V. D., Moschner, J., Giannis, A., Frolov, A. & Hoffmann, R. (2015) Sensitive and site-specific identification of carboxymethylated and carboxyethylated peptides in tryptic digests of proteins and human plasma. J. Prot. Res. 14: 768-77. PMID: 25423611

161. Prasse, A.A., Zauner, T., Büttner, K., Hoffmann, R. & Zuchner, T. (2014) Improvement of an antibody-enzyme coupling yield by enzyme surface supercharging. BMC Biotechnology 14: 88. PMID: 25326050

160. Otvos, L., Knappe, D., Hoffmann, R., Kovalszky, I., Olah, J., Hewitson, T., Stawikowska, R., Stawikowski, M., Cudic, P., Lin, F., Wade, J., Surmacz, E. & Lovas, S. (2014) Development of second generation peptides modulating cellular adiponectin receptor responses. Frontiers in Chemistry 2 (93): 1-15. PMID: 25368867

159. Krizsan, A., Volke, D., Weinert, S., Sträter, N., Knappe, D. & Hoffmann, R. (2014) Insect derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome. Angew. Chemie Int. Ed. Engl. 53: 12236-9. PMID: 25220491

158. Frolov, A., Blüher, M. & Hoffmann R. (2014) Glycation sites of human plasma proteins are affected at different extents by hyperglycemic conditions in type 2 diabetes mellitus. Anal. Bioanal. Chem. 406: 5755-63. PMID: 25074545

157. Bollineni, R.C., Fedorova, M., Blüher, M. & Hoffmann, R. (2014) Carbonylated plasma proteins as potential biomarkers of obesity induced type 2 diabetes mellitus. J. Proteom. Res. 13: 5081-93. PMID: 25010493

156. Richter M., Mewes, A., Fritsch, M., Krügel, U., Hoffmann, R. & Singer, D. (2014) Doubly phosphorylated peptide vaccines to protect transgenic P301S mice against Alzheimer's Disease like tau aggregation. Vaccines 2: 601-23. DOI: 10.3390/vaccines2030601

155. Xue, J., Ray, R., Singer, D., Böhme, D. Burz, D.S., Rai, V., Hoffmann, R. & Shekhtman A. (2014) The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs. Biochemistry 53: 3327-35. PMID: 24824951

154. Annibal, A., Schubert, K., Wagner, U., Hoffmann, R. , Schiller, J. & Fedorova, M. (2014) New covalent modifications of phosphatidylethanolamine by alkanals: mass spectrometry based structural characterization and biological effects. J. Mass. Spectrom. 49: 557-69. PMID: 25044840

153. Frolov, A., Schmidt, R., Spiller, S., Greifenhagen, U., & Hoffmann, R. (2014) Arginine-derived advanced glycation end products generated in peptide-glucose mixtures during boiling, J. Agric. Food Chem. 62: 3626-35. PMID: 24725187

152. D'Hondt, M., Fedorova, M., Peng, C.Y., Gevaert, B., Taevernier, L., Hoffmann, R., De Spiegeleer, B. (2014) Dry heat forced degradation of buserelin peptide: kinetics and degradant profiling. Int. J. Pharm. 467: 48-9. PMID: 24657556

151. Genz, M., Köhler, V., Krauss, M., Singer, D., Hoffmann, R. , Ward, T.R. & Sträter, N. (2014) An Artificial Imine Reductase based on the RNase S scaffold. ChemCatChem 6: 736-740. DOI: 10.1002/cctc.201300995

150. Otvos, L., Vetter, S.W., Koladia, M., Knappe, D., Schmidt, R., Ostorhazi, E., Kovalszky, I., Bionda, N., Cudic, P. Surmacz, E., Wade, J.D. & Hoffmann R. (2014) The Designer Leptin Antagonist Peptide Allo-aca Compensates for Short Serum Half-life with Very Tight Binding to the Receptor. Amino Acids  46: 873–882. PMID: 24366600

149. Bollineni R.C., Hoffmann, R. & Fedorova, M. (2014) Proteome-wide profiling of carbonylated proteins and carbonylation sites in HeLa cells under mild oxidative stress conditions. Free Radic. Biol. Med. 68: 186-95. PMID: 24321318

148. Ostorházi, E., Nemes-Nikodém, É. , Knappe, D. & Hoffmann, R. (2014) In vivo activity of optimized apidaecin and oncocin peptides against a multiresistant, KPC-producing Klebsiella pneumoniae strain. Prot. Pept. Lett. 21: 368-73. PMID: 24164263

147. Knappe, D., Cassone, M., Nollmann, F.I., Otvos, L. & Hoffmann, R. (2014) Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity. Prot. Pept. Lett. 21: 321-9. PMID: 24164265

146. Stalmans, S., Wynendaele, E. Bracke, N., Knappe, D. & Hoffmann, R. , Peremans, K., Polis, I. & De Spiegeleer, B. (2014) Blood-Brain Barrier Transport of Short Proline-Rich Antimicrobial Peptides. Prot. Pept. Lett. 21: 399-406. PMID: 24164260

145. Zahn, M., Kieslich, B., Berthold, N., Knappe, D. & Hoffmann, R. & Sträter N. (2014) Structural identification of DnaK binding sites within bovine and sheep bactenecin Bac7. Prot. Pept. Lett. 21: 407-12. PMID: 24164259

144. Berthold, N. & Hoffmann, R. (2014) Cellular uptake of apidaecin 1b and related analogs in Gram-negative bacteria reveals novel antibacterial mechanism for proline-rich antimicrobial peptides. Prot. Pept. Lett. 21: 391-8. PMID: 24164266

143. Fedorova, M., Bollineni, R.C. & Hoffmann, R. (2014) Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies. Mass Spectrometry Reviews  33: 79-97. PMID: 23832618

142. Baum, F., Fedorova, M., Ebner, J., Hoffmann, R., Pischetsrieder, M. (2013) Analysis of the Endogenous Peptide Profile of Milk – Identification of 248 Mainly Casein-Derived Peptides. Journal of Proteome Research. 12: 5447-62. DOI: 10.1021/pr4003273

141. Stangner, T., Wagner, C., Singer, D., Angioletti-Uberti, S., Gutsche, C., Dzubiella, J., Hoffmann, R. & Kremer, F. (2013) Determining the Specificity of Monoclonal Antibody HPT-101 to Tau-Peptides with Optical Tweezers. ACS Nano. 7: 11388-96. PMID: 24279833

140. Genz, M., Singer, D., Hey-Hawkins, E., Hoffmann, R. & Sträter, N. (2013) Crystal Structure of Apo- and Metalated Thiolate containing RNase S as Structural Basis for the Design of Artificial Metalloenzymes by Peptide-Protein Complementation. Z. Anorg. Allg. Chem. 639: 2395-2400. DOI: 10.1002/zaac.201300410

139. Nollmann, F.I., Goldbach, T., Berthold, N. & Hoffmann, R. (2013) Controlled Systemic Release of Therapeutic Peptides from PEGylated Prodrugs by Serum Proteases. Angew. Chemie Int. Ed. Engl. 52: 7597-9. PMID: 23766125

138. Bollineni, R.C., Fedorova, M. & Hoffmann, R. (2013) Qualitative and quantitative evaluation of derivatization reagents for different types of protein-bound carbonyl groups. Analyst. 138: 5081-8. PMID: 23833766

137. Binellia, A., Marisaa, I., Fedorova, M., Hoffmann, R. & Rivaa, C. (2013) First evidence of protein profile alteration due to the main cocainemetabolite (benzoylecgonine) in a freshwater biological model. Aquatic Toxicology 140– 141: 268– 278. PMID: 23838174

136. Stangner, T., Singer, D., Wagner, C., Gutsche, C., Ueberschär, O., Hoffmann, R. & Kremer, F. (2013) FACS-sorted particles reduce the data variance in optical tweezers-assisted dynamic force spectroscopy measurements. Phys Biol. 10 (4): 046004. PMID: 23788010

135. Richter M., Hoffmann R. & Singer D. (2013) T cell epitope-dependent immune response in inbred mice (C57BL/6J, SJL/J, C3H/HeN) and transgenic P301S and Tg2576 mice. J. Pept. Sci. 19 (7): 441-451. PMID: 23728915

134. Zahn, M., Berthold, N., Kieslich, B., Knappe, D., Hoffmann, R. & Strater, N. (2013). Structural studies on the forward and reverse binding modes of peptides to the chaperone DnaK. J. Mol. Biol. J . Mol. Biol . 425: 2463-79. PMID: 23562829

133. Kreisig, T., Hoffmann, R. & Zuchner, T. (2013) Highly efficient Förster resonance energy transfer in a fast, serum-compatible immunoassay. Chembiochem 14: 699-702. PMID: 23532940

132. Milic, I., Hoffmann, R. & Fedorova, M. (2013) Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by ESI-MS/MS. Anal. Chem. 85: 156-62 . PMID: 23186270

131. Berthold, N., Czihal, P., Fritsche, S., Sauer, U., Schiffer, G., Knappe, D., Alber, G. & Hoffmann, R. (2013) Novel apidaecin 1b analogs with superior serum stabilities for treatment of Gram-negative pathogens. Antimicrob. Agents Chemother. 57: 402-409. PMID: 23114765

130. Luo, S., Hoffmann, R. , Skerka, S. & Zipfel, P.F. (2013) Glycerol-3-phosphate dehydrogenase 2 is a novel factor H, FHL-1 and plasminogen binding surface protein of Candida albicans . J. Inf. Dis . 207: 594-603. PMID: 23204165

129. Keitel, U., Schilling, E., Knappe, D., Al-Mekhlafi, M., Petersen, F., Hoffmann, R. & Hauschildt, S. (2012) Effect of antimicrobial peptides from Apis mellifera hemolymph and its optimized version Api88 on biological activities of human monocytes and mast cells. Inate. Immun. 19 (4): 355-67. PMID: 23112010

128. Hallström, T., Mörgelin, M., Barthel, D., Raguse, M., Kunert, A., Hoffmann, R. , Skerka, C. & Zipfel, P.F. (2012) Dihydrolipoamide dehydrogenase (Lpd) of Pseudomonas aeruginosa is a surface exposed bacterial immune evasion protein that binds three members of the Factor H family and plasminogen. J. Immunol . 189: 4939-50. PMID: 23071278

127. Hansen, A., Schäfer, I., Knappe, D., Seibel, P. & Hoffmann, R. (2012) Intracellular toxicity of proline-rich antimicrobial peptides shuttled into mammalian cells by the cell-penetrating peptide penetratin. Antimicrob. Agents Chemother. 56: 5194-201. PMID: 22850523

126. Fritsche, S., Knappe, D., Berthold, N., von Buttlar, H., Hoffmann, R. & Alber, G. (2012) Absence of in vitro innate immunomodulation by insect-derived short proline-rich antimicrobial peptides points to direct antibacterial action in vivo. J. Pept. Sci. 18 : 599-608 . PMID: 22936623

125. Knappe, D., Fritsche, S., Alber, G., Köhler, G., Hoffmann, R. & Müller, U. (2012) Oncocin derivative Onc72 is highly active against Escherichia coli in a systemic septicaemia infection mouse model. J. Antimicrob.. Chemother. 67: 2445-51 . PMID: 225729924

124. Czihal, P. Knappe, D. Fritsche, F., Zahn, M., Berthold, N., Piantavigna, S., Müller, U., Van Dorpe, S., Herth, N., Binas, A., Köhler, G., De Spiegeleer, B., Martin, L.L., Nolte, O., Strater, N., Alber, G. & Hoffmann, R. (2012) Api88 is a novel antibacterial designer peptide to treat systemic infections with multi-drug resistant Gram-negative pathogens. ACS Chem. Biol. 7: 1281-91. PMID: 22594381

123. Cook, S.L., Zimmermann, C.M., Singer, D., Fedorova, M., Hoffmann, R. & Jackson, G. P. (2012) Comparison of CID, ETD, and metastable atom-activated dissociation (MAD) of doubly- and triply-charged phosphorylated tau peptides. J. Mass Spectrom. 47: 786-94. PMID: 22707171

122. Dobslaff, K., Kreisig, T., Berthold, N., Hoffmann, R. & Züchner, T. (2012) Novel peptide-protein assay for identification of antimicrobial peptides by fluorescence quenching. Anal. Bioanal. Chem. 403: 2725-31. PMID: 22569846

121. Todorovski, T., Fedorova, M. & Hoffmann, R. (2012) Identification of isomeric 5-hydroxytryptophan- and oxindolylalanine-containing peptides by mass spectrometry. J. Mass Spectrom. 47: 453-9. PMID: 22689620

120. Teuber, K., Fedorova, M., Hoffmann, R. & Schiller, J. (2012) 4-Dinitrophenylhydrazine as a new reactive Matrix to analyze oxidized Phospholipids by MALDI-TOF Mass Spectrometry. Anal. Lett. 45: 968-976. tandfonline.com/doi/abs/10.1080/00032719.2012.670785

119. Langrock, T. & Hoffmann, R. (2012) Analysis of hydroxyproline in collagen hydrolysates. Methods Mol Biol. 828: 271-80. PMID: 22125151

118. Milic, I. Fedorova, M., Teuber, K., Schiller, J. & Hoffmann, R. (2011) Characterization of oxidation products from 1-palmitoyl-2-linoleoyl- sn -glycerophosphatidylcholine in aqueous solutions and their reactions with cysteine, histidine and lysine residues. Chem. Phys. Lipids 165: 186-196. PMID: 22222463

117. Wolf, A.I., Mozdzanowska, K., Williams, K.L., Singer, D., Richter, M., Hoffmann, R., Caton, A.J., Otvos, L. & Erikson, J.  (2011) Vaccination with M2e-Based Multiple Antigenic Peptides: Characterization of the B Cell Response and Protection Efficacy in Inbred and Outbred Mice. PLoS ONE 6: e28445, 1-11. PMID: 22180783

116. Otvos, L., Haspinger, E., LaRussa, F., Maspero, F., Graziano, P., Kovalszky, I., Lovas, S., Nama, K., Hoffmann, R., Knappe, K., Cassone, M., Wade, J. & Surmacz, E. (2011) Design and Development of a Peptide-based Adiponectin Receptor Agonist for Cancer Treatment. BMC Biotechnology 11: 90. PMID: 21974986

115. Zauner, T., Berger-Hoffmann, R., Müller, K., Hoffmann, R. & Zuchner, T. (2011) Highly adaptable and sensitive protease assay based on fluorescence resonance energy transfer. Anal. Chem. 83 (19): 7356-63. PMID: 21892820

114. Todorovski, T., Fedorova, M. & Hoffmann, R. (2011) Mass spectrometric characterization of peptides containing different oxidized tryptophan residues. J. Mass Spectrom. 46: 1030-8. PMID:22012669

113. Bollineni, R.C., Hoffmann, R. & Fedorova, M. (2011) Identification of protein carbonylation sites by two-dimensional liquid chromatography in combination with MALDI- and ESI-MS. J. Prot . 74: 2338-50. PMID: 21777707

112: Shvartsburg, A., Singer, D., Smith, R. & Hoffmann, R. (2011) Ion Mobility Separation of Isomeric Phosphopeptides from a Protein with Variant Modification of Adjacent Residues. Anal. Chem. 83 (13): 5078-85. PMID: 21667994

111: Bollineni, R.C., Fedorova, M. & Hoffmann, R. (2011) Identification of carbonylated peptides by tandem mass spectrometry using a precursor ion-like scan in negative ion mode. J. Prot. 74: 2351-9. PMID: 21669303

110. Kreisig T, Hoffmann R & Zuchner T (2011) Homogeneous Fluorescence-Based Immunoassay Detects Antigens Within 90 Seconds. Anal. Chem. 83 (11): 4281-7. PMID: 21495669

109. Xue, J., Rai, V., Singer, D., Chabierski, S., Xie, J., Reverdatto, S., Burz, D.S., Schmidt, A. M., Hoffmann, R. & Shekhtman A. (2011). Advanced Glycation End Product Recognition by the Receptor for AGEs. Structure 19 (5): 722-732. PMID: 21565706

108. Wagner, C., Singer, D., Ueberschär, O., Stangner, T., Gutsche, C., Hoffmann, R. & Kremer, F. (2011). Dynamic force spectroscopy on the binding of monoclonal antibodies and tau peptides, Soft Matter  7: 4370-4378, DOI: 10.1039/C0SM01414A

107. Knappe, D., Zahn, M., Sauer, U., Schiffer, G., Sträter, N. & Hoffmann, R. (2011) Rational Design of Oncocin derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK-Complex. Chembiochem 12 (6): 874-6. PMID: 21387510

106. Ermakova, I. I., Sakuta, G. A., Potekhina, M. A., Fedorova, M. A., Hoffmann, R . & Morozov, V. I. (2011) Major Chondroitin Sulfate Proteoglycans Identified in L6J1 Myoblast Culture. Biochemistry (Mosc) 76: 359-65. PMID: 21568872

105. McCubbin, G.A., Praporski , S., Piantavigna, S.,  Knappe, D., Bowie, J.H., Separovic, F., Hoffmann, R. & Martin, L.L. (2011) QCM-D Fingerprinting of Membrane-Active Peptides, Eur. Biophys. J. 40 (4): 437-46. PMID: 211615233

104. Simeonov, P., Berger-Hoffmann, R., Hoffmann, R., Sträter, N. & Züchner, T. (2011) Surface supercharged human enteropeptidase light chain shows improved solubility and refolding yield. Protein Eng. Des. Sel. 24 (3): 261-8. PMID: 21084283

103. Todorovski, T., Fedorova, M., Hennig, L. & Hoffmann, R. (2011) Synthesis of peptides containing 5-hydroxytryptophan, oxindolylalanine, N-formylkynurenine and kynurenine, J. Pept. Sci. 17 (4): 256-62. PMID: 21254311

102. Otvos, Jr., L., Kovalszky, I., Scolaro, L., Sztodola, A., Olah, J., Cassone, M., Knappe, D., Hoffmann, R., Lovas, S., Hatfield, M.P.D., Beko, G., Zhang, S., Wade, J.D. & Surmacz, E. (2011). Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation. Peptide Science 96: 117–125 , PMID: 20564005

101. Knappe, D., Kabankov, N. & Hoffmann R. (2011) Bactericidal oncocin derivatives with superior serum stabilities. Int. J. Antimic. Agents 37 (2): 166-70. PMID: 21185160

100. Ostorhazi E, Rozgonyi F, Sztodola A, Harmos, F., Kovalszky, I. , Szabo, D., Knappe, D., Hoffmann, R., Cassone, M., Wade, J.D., Bonomo, R.A. & Otvos, L. (2010) Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. J. Antimicr. Chemother. 65 (11): 2416-2422. PMID: 20810424

99. Kuettner, E.B., Kettner, K., Keim, A., Svergun, D.I., Volke, D., Singer, D., Hoffmann, R., Müller, E.-C., Otto, A., Kriegel, T.M., & Sträter, N. (2010) Crystal Structure of the Hexokinase KlHxk1 of Kluyveromyces lactis. A molecular basis to understand the control of yeast hexokinase functions via covalent modification and oligomerization. J. Biol. Chem. 285 (52): 41019-33. PMID: 20943665

98. Ehrlich, H., Deutzmann, R., Brunner, E., Cappellini, E., Koon, H., Solazzo, C., Yang, Y., Ashford, D., Thomas-Oates, J., Lubeck, M., Baessmann, C., Langrock, T., Hoffmann, R., Wörheide, G., Reitner, J., Simon, P., Tsurkan, M., Ereskovsky, A.V., Kurek, D., Bazhenov, V.V., Hunoldt, S., Mertig, M., Vyalikh, D.V., Molodtsov, S.L., Kummer, K., Worch, H., Smetacek, V. & Collins, M.J. (2010) Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen. Nature Chem. 2 (12): 1084-1088. PMID: 21107374

97. Knappe, D., Piantavigna, S., Hansen, A., Mechler, A., Binas, A., Nolte, O., Martin, L.L., & Hoffmann, R. (2010) Oncocin (VDKPPYLPRPRPPRRIYNR-NH 2 ): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens. J. Med. Chem. 53 (14): 5240-7. PMID: 20565063.

96. Singer, D., Kuhlmann, J., Muschket, M. & Hoffmann, R. (2010) Separation of mulitiphosphorylated peptide isomers by hydrophilic interaction chromatography on an aminopropyl phase. Anal. Chem. 82 (15): 6409-14. PMID: 20593796.

95.Knappe, D., Henklein, P., Hoffmann, R., & Hilpert, K. (2010) Easy strategy to protect antimicrobial peptides for fast degradation in serum.Antimicrob Agents Chemother 54 (9): 4003-5. PMID: 20585128 .

94. Frolov, A. & Hoffmann, R. (2010) Identification and relative quantification of specific glycation sites in human serum albumin for type 2 diabetes mellitus in plasma. Anal Bioanal. Chem. 397 (6): 2349-2356. PMID: 20496030.

93. Fedorova, M., Todorovsky, T., Kuleva, N. & Hoffmann, R. (2010) Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress. Proteomics 10 (14): 2692–2700. PMID: 20455213.

92. Fedorova, M., Frolov, A. & Hoffmann, R. (2010) Fragmentation behavior of Amadori-peptides obtained by non-enzymatic glycosylation of lysine residues with ADP-ribose in tandem mass spectrometry. J. Mass Spectrom 45 (6): 664-9. PMID: 20527035.

91. Singer, D., Zauner, T., Genz, M., Hoffmann, R., & Zuchner, T. (2010) Synthesis of pathological and non-pathological human exon 1 huntingtin. J. Pept. Sci. 16 (7): 358-63. PMID: 20552561.

90. Fedorova, M., Kuleva, N., & Hoffmann, R. (2010) Identification, quantification and functional aspects of skeletal muscle protein-carbonylation in vivo during acute oxidative stress. J. Proteome Res. 9 (5): 2516-26. PMID: 20377239 .

89. Birkenmeier,G., Stegemann, C., Hoffmann, R., Günther, R., Huse, K. & Birkemeyer, C. (2010) Posttranslational Modification of Human Glyoxalase 1 Indicates Redox-Dependent Regulation. Plos One 5 (4): e10399. PMID: 20454679

88. Fedorova, M., Kuleva, N., & Hoffmann, R. (2010). Identification of cysteine, methionine and tryptophan residues of actin oxidized in vivo during oxidative stress. J. Proteome Res. 9 (3): 1598-609. PMID: 20063901

87. Hanisch, K., Sininen, H., Alafuzoff, I., & Hoffmann, R. (2010) Analysis of human Tau in cerebrospinal fluid. J. Proteome Res. 9 (3): 1476-82. PMID: 20067323

86. Stegemann, C., Tsvetkova, E. V., Aleshina, G. M., Lehrer, R. I., Kokryakov, V. N. & Hoffmann, R. (2010)
De-novo sequencing of two new cyclic beta-defensins from baboon ( Papio hamadryas ) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun. Mass Spectrom. 24 (5): 599-604. PMID: 20155756

85. Ehrlich, H., Hanke, T., Simon, P., Born, R., Fischer, C., Frolov, A., Langrock, T., Hoffmann, R., Schwarzenbolz, U., Henle, T. Bazhenov, V.V., & Worch H. (2010). Carboxymethylation of the fibrillar collagen with respect to formation of hydroxyapatite. J. Biomed. Mat. Res. B Appl Biomater. 92 (2): 542-54. PMID: 19957363

84. Singer, D, Soininen, H., Alafuzoff, I., & Hoffmann, R. (2009). Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease. Anal. Bioanal. Chem. 395: 2263-2267. PMID: 19821112

83. Zuchner, T., Schumer, F. Berger-Hoffmann, R., Müller, K., Lukas, M. Zeckert, K., Marx, J., Hennig, H. & Hoffmann, R. (2009). Highly sensitive protein detection based on lanthanide chelates with antenna ligands providing a linear range of five orders of magnitude. Anal. Chem. 81 (22): 9449-53. PMID: 19817408

82. Fedorova, M., Kuleva, N. & Hoffmann, R. (2009). Reversible and irreversible modifications of skeletal muscle proteins in a rat model of acute oxidative stress. Biochim. Biophys. Acta. 1792 (12): 1185-93. PMID: 19786098

81. Vikhoreva, N.N., Vikhorev, P.G. Fedorova, M., Hoffmann, R. & Kuleva, N. (2009) The in vitro motility parameters of actin filaments from Mytilus edulis exposed in vivo to copper ions Arch. Biochem. Biophys. 491 (1-2): 32-8. PMID: 19796626

80. Nielsen-Marsh, C.M., Stegemann, C., Hoffmann, R., Smith, T., Feeney, R., Toussaint, M., Harvati, K., Panagopoulou, E. & Hublin,J.-J., & Richards, M.P. (2009) Extraction and sequencing of human and Neanderthal mature enamel proteins using MALDI-TOF/TOF MS. J. Archaeol. Sci. 36: 1758-63.

79. Czihal, P. & Hoffmann, R. (2009) Mapping of apidaecin regions relevant for antimicrobial activity and bacterial internalization. Int. J. Pept. Res. Ther. 15: 157-164

78. Piantavigna, S., Czihal, P., Mechler, A., Richter, M., Hoffmann, R. & Martin, L.L. (2009) Cell penetrating Apidaecin peptides exhibit thresholded interactions with biomimetic phospholipid membranes, Int. J. Pept. Res. Ther. 15: 139-146 http://www.springerlink.com/content/1573-3149

77. Stegemann, C., Kolobov, A. Jr., Leonova, Y.F., Knappe, D., Shamova, O., Ovchinnikova, T.V., Kokryakov, V.N. & Hoffmann, R. (2009) Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles. Proteomics 9: 1364-73. PMID: 19253295

76. Shamova, O., Orlov, D., Stegemann, C., Czihal, P., Hoffmann, R., Brogden, K., Kolodkin, N.,  Sakuta, G., Tossi, A.,  Sahl, H.-G., Kokryakov, V. & Lehrer, R. (2009) ChBac3.4: A novel proline-rich antimicrobial peptide from goat leukocytes. Int. J. Pept. Res. Ther. 15: 31-42

75. Ehrlich, H., Hanke, T., Frolov, A., Langrock, T., Hoffmann, R., Fischer, C., Schwarzenbolz, U., Henle, T., Born, R. & Worch, H. (2009) Modification of Collagen in vitro with respect to formation of  Ne-Carboxymethyllysine. Int. J. Biol. Macromol. 44: 51-56. PMID: 18984004

74. Andreazza, H.J., Fitzgerald, M., Bilusich, D., Hoffmann, R., Hoffmann, P., Eichinger, P.C. & Bowie, J.H. (2008) Characteristic negative ion fragmentations of deprotonated peptides containing post-translational modifications: mono-phosphorylated Ser, Thr and Tyr. A joint experimental and theoretical study. Rapid Commun. Mass Spectrom. 22: 3305-12. PMID: 18821730

73. Singer, D. & Hoffmann, R. (2008) Synthesis of O-phosphopeptides on solid phase. Methods Mol. Biol. 494: 209-222. PMID: 18726576

72. Frolov, A. & Hoffmann R. (2008) Separation of Amadori peptides from their unmodified analogs in ion-pairing RP-HPLC with heptafluorobutyric acid as ion-pair reagent. Anal. Bioanal. Chem. 392 (6):1209-14. PMID: 18813915

71. Stegemann, C. & Hoffmann, R. (2008) Sequence analysis of antimicrobial peptides by tandem mass spectrometry. Methods Mol Biol. 494: 31-46. PMID:18726567

70. Xie, J., Reverdatto, S., Frolov, A., Hoffmann, R., Burz, D.S. & Shekhtman A. (2008) Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE), Journal of Biological Chemistry 283: 27255-69. PMID: 18667420

69. Ehrlich, H., Hanke, T., Born, R., Fischer, C., Frolov, A., Langrock, T., Hoffmann, R., Schwarzenbolz, U., Henle, T., Simon, P., Geiger, D., Bazhenov, V.V. & Worch, H. (2008) Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system. J. Membrane Sci., Journal of Membrane Science 326: 254-259.

68. Volke, D. & Hoffmann, R. (2008) Quantitative Proteomics by Fluorescent Labeling of Cysteine Residues using a Set of Two Cyanine-based or Three Rhodamine-based Dyes. Electrophoresis 29 (22): 4516-4526. PMID: 19035404

67. Knappe, D., Otvos, L., De Pascali, F., Cassone, M., Scolaro, L., Abbadessa, G., Carillo-Infante, C., Kiani, M., Donelson, F., Hoffmann, R. & Surmacz, E. (2008) Drug development-targeted screening of leptin agonist glycopeptides. Int. J. Pept. Res. Ther. 14: 247-254 http://www.springerlink.com/content/1573-3149

66. Morell, M., Czihal, P., Hoffmann, R., Otvos, L., Avilés, F.X. & Ventura, S (2008) Monitoring the interference of protein-protein interactions in vivo by bimolecular fluorescence complementation (BIFC): the DnaK case. Proteomics 8 (17): 3433-42. PMID: 18686297

65. Muetzelburg, M.V. & Hoffmann, R. (2008). Separation of multiphosphorylated peptide isomers by capillary zone electrophoresis, Electrophoresis 21: 4381-5. PMID: 18942677

64. Otvos, L., Terrasi, M., Cascio, S., Cassone, M., Abbadessa, G., di Pascali, F., Scolaro, L., Knappe, D., Stawikowski, M., Cudic, P., Wade, J.D., Hoffmann, R. & Surmacz, E. (2008). Development of a Pharmacologically Improved Peptide Agonist of the Leptin Receptor, Biochimica et Biophysica Acta 1783: 1745-54. PMID: 18555805

63. Singer, D., Herth, N., Kuhlmann, J., Holland-Nell, K., Beck-Sickinger, A.G. & Hoffmann, R. (2008). Mapping of phosphorylation-dependent anti-tau monoclonal antibodies in immunoblots using human tau-constructs synthesized by native chemical ligation. Biochem. Biophys. Res. Comm. 367 (2): 318-22. PMID: 18162172

62. Frolov, A. & Hoffmann, R. (2008). Analysis of Amadori peptides enriched by boronic acid affinity chromatography, Ann. N. Y. Acad. Sci. 1126: 253-6. PMID: 18448825


61. Kunert, A. Losse, J., Gruszin, C., Hühn, M., Kändler, K., Mikkat, S., Volke, D., Hoffmann, R., Jokiranta, T.S., Seeberger, H., Möllmann, U., Hellwage, J. & Zipfel, P.F. (2007). Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a Factor H and plasminogen-binding protein. J. Immunol. 179 (5): 2979-88 . PMID: 17709513

60. Frolov, A., Singer, D. & Hoffmann, R. (2007). Solid-phase synthesis of glucose-derived. Amadori peptides. J. Pept. Sci. 13: 862-867. PMID: 17883244

59. Lepetit, B., Volke, D., Szabo, M., Hoffmann, R., Garab, G., Wilhelm, C. & Goss, R. (2007). Spectroscopic and molecular characterization of the oligomeric antenna of the diatom Phaeodactylum tricornutum. Biochemistry 46 (34): 9813-22. PMID: 17672483

58. Porzig, R., Singer, D. & Hoffmann, R. (2007). Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein.Biochem. Biophys. Res. Comm. 358: 644-649. PMID: 17499212

57. Kellner, H., Jehmlich, N., Benndorf, D., Hoffmann, R., Rühl, M., Hoegger, P.J., Majcherczyk, A., Kües, U., von Bergen, M. & Buscot, F. (2007); Detection, quantification and identification of fungal extracellular laccases using polyclonal antibody and mass spectrometry.  Enzyme and Microbial Technology 41 694-701.

56. Sykora, C., Hoffmann, R. & Hoffmann, P. (2007). Enrichment of multiphosphorylated peptides by immobilized metal affinity chromatography using Ga(III)- and Fe(III)-complexes. Prot. Pept. Lett. 14: 489-496. PMID: 17584176

55. Zhang, Q., Frolov, A., Tang, N., Hoffmann, R., van de Goor, T.O. & Smith, R.D. (2007). Application of electron transfer dissociation mass spectrometry in analyses of non-enzymatically glycated peptides. Rapid Commun. Mass. Spectrom. 21: 661-666. PMID: 17279487

54. Langrock, T., García-Villar, N. & Hoffmann, R. (2007). Analysis of Hydroxyproline by Reversed-Phase HPLC and Mass Spectrometry. J. Chromatogr. B. 847: 282-288. PMID: 17085085

53.Frolov, A., Hoffmann, P. & Hoffmann, R. (2006). Fragmentation behavior of glycated peptides derived from D-glucose, D-fructose and D-ribose in tandem mass spectrometry. J. Mass Spectrom. 41 (11): 1459-1469. PMID: 17063450

52. Singer, D., Lehmann, J., Hanisch, K., Härtig, W. & Hoffmann R. (2006). Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease. Biochem. Biophys. Res. Comm. 346 (3): 819-28. PMID: 16781671

51. Volke, D. & Hoffmann, R. (2006). Purification of bovine Tau versions by affinity chromatography. Prot. Expr. Purif. 50: 37-42. PMID: 16750637

50. Härtig, W., Lehmann, J., Stieler, J., Singer, D., Grosche, J., Arendt, T. & Hoffmann, R. (2006). Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. NeuroReport 17 (9): 869-874. PMID: 16738478

49. Volke, D. & Hoffmann, R. (2006). Characterization of bovine Tau-preparations by two-dimensional gel electrophoresis. Prot. Pept. Lett. 13 (6): 617-625. PMID: 16842118

48. Cook, J.R., Lee, J.-H., Yang, Z.H., Krause, C.D., Herth, N., Hoffmann, R. & Pestka, S. (2006) FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. Biochem. Biophys. Res. Commun. 342 (2): 472-81. PMID: 16487488

47. Langrock, T., Czihal, P. & Hoffmann, R. (2006). Amino acid analysis by hydrophilic interaction chromatography coupled on-line to electrospray ionization mass spectrometry. Amino Acids 30: 291-7. PMID: 16622599

46. Frolov, A., Singer, D. & Hoffmann, R. (2006). Site-Specific Synthesis of Amadori-Modified Peptides on Solid Phase. J. Pept. Sci. 12: 389-95. PMID: 16342332

45. Singer, D., Volke, D. & Hoffmann, R. (2005). Characterization of phosphorylation-dependent anti-Tau antibodies. J. Pept. Res. Ther. 11: 279-289.

44. Otvos, L. Jr, Wade, J.D., Lin, F., Condine, B.A., Hanrieder, J. & Hoffman, R. (2005). Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates. J. Med. Chem. 48: 5349-59. PMID: 16078852

43. Lee, J.H., Cook, J.R., Yang, Z.H., Mikrochnitchenko, O., Gunderson, S., Felix, A.M., Herth, N. Hoffmann, R. & Pestka, S. (2005). PRMT7: A new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. J Biol Chem. 280: 3656-64. PMID: 15494416

42. Chie, L., Cook, J.R., Chung, D., Hoffmann, R., Yang, Z., Kim, Y., Pestka, S. & Pincus, M.R. (2003). A protein methyl transferase, PRMT5, selectively blocks oncogenic ras-p21 mitogenic signal transduction. Ann Clin Lab Sci. 33: 200-207. PMID: 12817625

41. Bencivengo, A.M., Cudic, M., Hoffmann, R. & Otvos, L. (2003). The efficacy of the antibacterial peptide, pyrrhocoricin, is finely regulated by its amino acid residues and active domains. Lett. Pept. Sci. 8: 201-209. www.springerlink.com

40. Franken, S., Junghans, U., Roßlenbroich, V., Baader, S.L., Hoffmann, R., Gieselmann, V., Viebahn, C. & Kappler, J. (2003). Collapsin response mediator proteins of neonatal rat brain interact with chrondroitin sulfate. J. Biol. Chem. 278: 3241-50. PMID: 12444086

39. Kragol, G., Hoffmann, R., Chattergoon, M.A., Lovas, S., Cudic, M., Bulet, P., Condie, B.A., Rosengren, K.J., Montaner, L.J., & Otvos, L., Jr. (2002). Identification of crucial residues for the antibacterial activity of the proline rich peptide, pyrrhocoricin. Eur. J. Biochem. 269: 4226-4237. PMID: 12199701

38. Pipkorn, R., Boenke, C., Gehrke, M. & Hoffmann, R. (2002). High-throughput peptide synthesis and peptide purification strategy at the low micromol-scale using the 96-well format. J. Pept. Res. 59: 105-114. PMID: 11985704

37. Wehofsky, M. & Hoffmann, R. (2002). Automated isotopic deconvolution and deisotoping of electrospray mass spectra. J. Mass Spectrom. 37: 223-229. PMID: 11857767

36. Hoffmann, R., Wehofsky, M. & Metzger, S. (2001). Neutral loss und parent ion analysis in MALDI-MS using an ion-gate scanning mode. Anal. Chem. 73: 4845-4851. PMID: 11681460

35. Pfeifer, T., Klaus, U., Hoffmann, R. & Spiteller, M. (2001) Characterization of humic substances using atmospheric pressure chemical ionization and electrospray ionisation mass spectrometry combined with size-exclusion chromatography. J. Chrom. A 926: 151-159. PMID: 11554407

34. Kragol, G., Lovas, S., Varadi, G., Condie, B.A., Hoffmann, R. & Otvos, L. Jr. (2001). The Antibacterial Peptide Pyrrhocoricin Inhibits the ATPase Actions of DnaK and Prevents Chaperone Assisted Protein Folding. Biochemistry, 40: 3016-3026. PMID: 11258915

33. Wehofsky, M., Hoffmann, R., Hubert, M. & Spengler, B. (2001). Isotopic deconvolution of MALDI-mass spectra for substance-class specific analysis of complex samples. Eur. J. Mass Spectrom. 7: 39-46.

32. Metzger, S. & Hoffmann, R. (2000). Studies on the dephosphorylation of phosphotyrosine-containing peptides during the post-source decay in MALDI. J. Mass Spectrom. 35: 1165-1177. PMID: 11110089

31. Daly, N.L., Hoffmann, R. Otvos, L. Jr. & Craik, D.J. (2000) The role of phosphorylation in the conformation of tau peptides implicated in Alzheimer‘s disease. Biochemistry 39: 9039-9046. PMID: 10913317

30. Kappler, J., Franken, S., Junghans, U., Hoffmann, R., Linke, T., Müller, H.W. & Koch, K.-W. (2000) Glycosaminoglycan-binding properties and secondary structure of the C-terminus of Netrin-1. Biochem. Biophys. Res. Commun. 271: 287-291.. PMID: 10799289

29. Otvos, L. Jr., Bokonyi, K., Varga, I., Otvos, B.I., Hoffmann, R., Ertl, H.C.J., Wade, J.D., McManus, A.M., Craik, D.J. & Bulet, P., Jr. (2000). Insect peptides with improved protease-resistance protect mice against bacterial infection. Protein Sci, 9: 742-749. PMID: 10794416

28. Otvos, L. Jr., Pease, A.M., Bokonyi, K., Giles-Davis, W., Rogers, M.E., Hintz, P.A., Hoffmann, R. & Ertl, H.C.J. (2000). In situ stimulation of a T helper cell hybridoma with a cellulose-bound peptide antigen. J. Immunol. Meth. 233: 95-105. PMID: 10648860

27. Desimone, M., Krüger, M., Wessel, T., Wehofsky, M., Hoffmann, R. & Wagner, E. (2000). Purification and characterization of an aminopeptidase from the chloroplast stroma of barley leaves by chromatographic and electrophoretic methods. J. Chromatogr. B 737: 285-293. PMID: 10681066

26. Cudic, M., Bulet, P., Hoffmann, R., Craik, D.J. & Otvos, L. Jr. (1999). Chemical synthesis, antibacterial activity and conformation of diptericin, an 82-mer peptide originally isolated from insects. Eur. J. Biochem. 266: 549-558. PMID: 10561597

25. Hoffmann, R., Metzger, S., Spengler, B. & Otvos, L., Jr. (1999). Sequencing of peptides phosphorylated on serines and threonines by post-source decay in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom. 34: 1195-1204. PMID: 10548813

24. Hoffmann, R., Craik, D.J., Bokonyi, K., Varga, I. & Otvos, L., Jr. (1999). High level of aspartic acid-bond isomerization during the synthesis of an N-linked t glycopeptide. J. Peptide. Res. 5: 442-456. PMID: 10580643

23. Ctortecka, B., Tröger, W., Mallion, S., Butz, T., Hoffmann, R. & the ISOLDE-Collaboration, Jr. (1999). Hg coordination studies of oligopeptides containing cysteine, histidine and tyrosine by 199mHg TDPAC. Hyperfine Interactions 120/121: 737-743.

22. Hoffmann, R., Bulet, P., Urge, L. & Otvos, L., Jr. (1999). Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects. Biochim. Biophys. Acta 1426: 459-67. PMID: 10076062

21. McManus, A.M., Otvos, L., Jr., Hoffmann, R. & Craik, D. (1999). Conformational studies by NMR of the anti-microbial peptide, drosocin and its non-glycosylated derivative: effects of glycosylation on solution conformation. Biochemistry 38: 705-714. PMID: 9888811

20. Hoffmann, R., Craik, D.J., Pierens, G., Bolger, R.E. & Otvos, L., Jr. (1998). Phosphorylation of the C-terminal sites of human p53 reduces non-sequence specific DNA binding as modeled with synthetic peptides. Biochemistry 37: 13755-13764. PMID: 9753464

19. Otvos, L. Jr., Hoffmann, R., Xiang, Z.Q., O, I., Deng, H., Wysocka, M., Pease, A.M., Rogers, M.E., Blaszczyk Thurin, M. & Ertl, H.C.J. (1998) A monoclonal antibody to a multiphosphorylated, conformational epitope at the carboxy terminus of p53. Biochem. Biophys. Acta 1404: 457-474. PMID: 9739174

18. Otvos. L. Jr., Pease, A.M., Wade, J.D. & Hoffmann, R. (1998) N glycosylation of the fourth repeat of human Tau protein abolishes binding to the C terminal acidic Tau binding segment of ß tubulin. Prot. Pept. Lett. 5: 207-213.

17. Hoffmann, R., Bril, G. & Otvos, L. Jr. (1998). Prediction of retention times of peptide nucleic acids during reversed-phase high performance liquid chromatography. J. Chromatogr. A 814: 111-119. PMID: 9718690

16. Tholey, A. & Hoffmann, R. (1997). Solid phase synthesis of tyrosyl H-phosphonopeptides and methyl-phosphonopeptides. J. Peptide Sci. 3: 186-192. PMID: 9230484

15. Jicha, G.A., Lane, E., Vincent, I., Otvos, L. Jr., Hoffmann, R. & Davies, P. (1997). A conformation and phosphorylation dependent antibody recognizing the paired helical filaments of Alzheimer's disease. J. Neurochem. 69: 2087-2095. PMID: 9349554

14. Hoffmann, R., Segal M. & Otvos, L., Jr. (1997). Separation of sets of mono- and diphosphorylated peptides by reversed-phase high performance liquid chromatography. Analytica Chimica Acta 352: 327-333 SienceDirect

13.Hoffmann, R., Vasko M. & Otvos, L., Jr. (1997). Serum stability of phosphopeptides. Analytica Chimica Acta 352: 319-325 SienceDirect

12. Hoffmann, R., Lee, V. M.-Y., Leight, S., Varga, I. & Otvos, L. Jr. (1997). Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites. Biochemistry 36: 8114-8124. PMID: 9201960

11. Hoffmann, R., Dawson, N.F., Wade, J.D. & Otvos, L., Jr. (1997). Oxidized and phosphorylated synthetic peptides corresponding to the second and third tubulin-binding repeats of the Tau protein reveal structural features of paired helical filaments assembly. J. Peptide Res. 50: 132-142. PMID: 9273897

10. Hoffmann, R., Hoffmann, T., Tholey, A. & Kalbitzer, H.R. (1997). Synthesis and NMR-spectroscopy of peptides containing either phosphorylated or phosphonylated cis- or trans-4-hydroxy-L-proline. J. Peptide Res. 49: 163-173. PMID: 9147312

9. Troeger, W., Lippert, C., Schmidt, P., Schmidt, U., Butz, T., Hoffmann, R., Zeppezauer, M. & the ISOLDE Collaboration. (1996). Hg-coordination studies of cysteine containing oligopeptides. Z. Naturforsch. 51a: 427-430.

8. Hoffmann, R. & Otvos, L., Jr. (1996). Selective dimerization of cysteines in glycopeptides and phosphopeptides. Lett. Pept. Sci. 3: 371-377.

7. Hoffmann, R., Tholey, A., Hoffmann, T. & Kalbitzer, H.R. (1996). Solid-phase synthesis of H- and methyl-phosphonopeptides. Int. J. Peptide Protein Res. 47: 245-253. PMID: 8738649

6. Schneider, K.H., Jakel, G., Hoffmann, R. & Giffhorn, F. (1995). Enzyme evolution in Rhodobacter sphaeroides: Selection of a mutant expressing a new galactitol dehydrogenase and biochemical characterization of the enzyme. Microbiology 141: 1865-1873. PMID: 7551050

5. Berger, R.G., Hoffmann, R., Zeppezauer, M., Wagner-Redeker, W., Maljers, L., Ingendoh, A. & Hillenkamp, F. (1995). Separation and characterization of bovine histone H1 subtypes by combined ion-exchange and reversed-phase chromatography and mass spectrometry. J. Chromatogr. A 711: 159-165. PMID: 7496487

4. Hoffmann, R. , Wachs, W.O., Berger, R.G., Kalbitzer, H.R., Waidelich, D., Bayer, E., Wagnerredeker, W. & Zeppezauer, M (1995). Chemical phosphorylation of the peptides GGXA (X=S,T,Y): An evaluation of different chemical approaches. Int. J. Peptide Protein Res. 45: 26-34. PMID: 7775006

3. Hoffmann, R., Reichert, I., Wachs, W.O., Zeppezauer, M. & Kalbitzer, H.R. (1994). 1H and 31P NMR spectroscopy of phosphorylated model peptides. Int. J. Peptide Protein Res. 44: 193-198. PMID: 7529751

2. Zeppezauer, M., Hoffmann, R., Schönberger, A., Rawer, S., Rapp, W. & Bayer, E. (1993). Hydrophilic-polystyrene-polyoxyethylene graft polymer beads as carrier of antigenic peptides for in vivo and in vitro immunization techniques: Applications to the non-catalytic zinc loop of HLADH isozymes and to histone fragments. Z. Naturforsch. 48b: 1801-1806.

1. Wolber, V., Rensland, H., Brandmeier, B., Sagemann, M., Hoffmann, R., Kalbitzer, H.R. & Wittinghofer, A. (1992). Expression, purification, and biochemical characterization of the human immunodificiency virus 1 nef gene product. Eur. J. Biochem. 205: 1115-1121. PMID: 1533585

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