Gottfried Alber has been Professor of Immunology (Veterinary Medicine) at the University of Leipzig since 1996 - after research stays in Germany and abroad. He is a licensed veterinarian and is involved in immunological research and teaching. His scientific interests focus on basic research as well as vaccine development. At the Faculty of Veterinary Medicine in Leipzig, he established the Institute of Immunology, which is located at the Biotechnological-Biomedical Center (BBZ).
In teaching, he is responsible for the subjects Immunology and Laboratory Animal Science. He is particularly interested in introducing veterinary students to career perspectives in research in his teaching.
Since 2014, he has chaired the Research Commission of the Faculty of Veterinary Medicine and actively contributes to the promotion of young researchers as well as to scientific networking and focus formation at the Faculty of Veterinary Medicine.
- 01/1987 - 12/1988
Postdoc at the Max Planck Institute for Immunobiology
- 01/1988 - 12/1991
Postdoc at National Institutes of Health, Bethesda, MD, USA (Fogarty International Program)
- 01/1992 - 12/1992
Research associate at the Max Planck Institute for Immunobiology (habilitation stipend by the German Research Foundation)
- 01/1993 - 03/1996
Project leader for the field of host defence in preclinical research, Dept. of Infectious Diseases, F. Hoffmann-La Roche AG, Basel, Switzerland
- since 04/1996
Professor of Immunology (Veterinary Medicine) at the Faculty of Veterinary Medicine, University of Leipzig
- since 07/1996
Habilitation and Venia legendi for Immunology at the Faculty of Veterinary Medicine, University of Zurich, Zurich, Switzerland
- 10/1978 - 02/1984
Study of Veterinary Medicine (Free University of Berlin)
- 03/1984 - 12/1986
Dissertation at the Department of Veterinary Medicine, Freie Universität Berlin
The current scientific focus of Gottfried Alber is:
- Cellular and humoral immunity during infection of pigs with Streptococcus suis
- Phenotype and function of canine non-conventional T cells
- T-helper subpopulations in the murine model of pulmonary cryptococcosis (Cryptococcus neoformans), model of allergic bronchopulmonary mycosis), antigen identification by immunoproteomic techniques
Together with Christoph Baums (Institute of Bacteriology and Mycology), Gottfried Alber's team is working on the investigation of the host-pathogen interaction of S. suis. In addition to basic research, the goal - together with a pharmaceutical company - is to develop an S. suis vaccine.
Since 2009, non-conventional canine T-cell populations have been studied.
Fungal infections of humans and animals are still a challenge for therapy and vaccination prophylaxis. Since 1993, the research group of Gottfried Alber has been dealing with the fungus Cryptococcus neoformans. This has led to the characterization of the role of the interleukin-12 cytokine family in the antifungal immune response. Likewise, mechanisms of a misdirected T-helper 2 immune response could be deciphered. Currently, new immunogenic proteins recognized by antibodies have been identified in patients with cryptococcal meningitis.
Our research projects are mainly funded by the German Research Foundation.
- Immunglobulin M-degrading enzyme of Streptococcus suis (IdeSsuis): modulation of B-cell function and consequences for mucosal colonizationAlber, GottfriedDuration: 04/2020 - 09/2023Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Immunologie; Institut für Bakteriologie und Mykologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
- Protection against Streptococcus suis across serotypesAlber, GottfriedDuration: 10/2020 - 12/2022Funded by: Sächsische WirtschaftInvolved organisational units of Leipzig University: Immunologie; Institut für Bakteriologie und Mykologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
- Antigen identification and characterization of adaptive immune responses in severe Equine Asthma (sEA)Schnabel, Christiane LilianeDuration: 01/2020 - 12/2022Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Immunologie; Bioanalytik; Strukturanalytik von Biopolymeren; Veterinärpharmakologie und Arzneiverordnungslehre; Institut für Parasitologie; Institut für Bakteriologie und Mykologie; Klinik für Pferde
- Functional analysis of nonconventional TCRαβ+ CD4-CD8α- double-negative canine T cellsEschke, MariaDuration: 08/2021 - 07/2024Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Molekulare Pathogenese; Institut für Immunologie
- Ebner, F.; Schwiertz, P.; Steinfelder, S.; Pieper, R.; Zentek, J.; Schütze, N.; Baums, C. G.; Alber, G.; Geldhof, P.; Hartmann, S.Pathogen-Reactive T Helper Cell Analysis in the PigFrontiers in Immunology. 2017.
- Gressler, A. E.; Volke, D.; Firacative, C.; Schnabel, C. L.; Müller, U.; Krizsan, A.; Schulze-Richter, B.; Brock, M.; Brombacher, F.; Brombacher, F.; Escandon, P.; Hoffmann, R.; Alber, G.Identification of Disease-Associated Cryptococcal Proteins Reactive With Serum IgG From Cryptococcal Meningitis PatientsFront. Immunol.. 2021.
- Rabiger, F. V.; Rothe, K.; von Buttlar, H.; Bismarck, D.; Büttner, M.; Moore, P.; Eschke, M.; Alber, G.Distinct Features of Canine Non-conventional CD4(-)CD8 alpha(-) Double-Negative TCR alpha beta(+) vs. TCR gamma delta(+) T CellsFrontiers in Immunology. 2019.
- Rabiger, F. V.; Bismarck, D.; Protschka, M.; Köhler, G.; Moore, P. F.; Büttner, M.; von Buttlar, H.; Alber, G.; Eschke, M.Canine tissue-associated CD4+CD8α+ double-positive T cells are an activated T cell subpopulation with heterogeneous functional potentialPLOS ONE. 2019.
- Firacative, C.; Greßler, A. E.; Schubert, K.; Schulze-Richter, B.; Müller, U.; Brombacher, F.; von Bergen-Tomm, G. M.; Alber, G.Identification Of T Helper (Th)1- And Th2-Associated Antigens Of Cryptococcus Neoformans In A Murine Model Of Pulmonary InfectionScientific reports. 2018. 8 (1). p. 2681
- Molekulare Pathogenese; Bioanalytik; Institut für Immunologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Identifizierung von Antigenen des Pilzes Cryptococcus neoformansStart Date of Collaboration: 01/07/2016Involved persons: Alber, Gottfried; Firacative, Carolina; Hoffmann, Ralf; Gressler, Elisabeth
- Molekulare Pathogenese; Institut für Bakteriologie und Mykologie; Institut für Immunologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Zelluläre Immunreaktionen von Schweinen bei Infektion und VakzinierungStart Date of Collaboration: 01/04/2015Involved persons: Alber, Gottfried; Baums, Christoph Georg
- Molekulare Pathogenese; Medizinische Fakultät und Universitätsklinikum AöR; Institut für Immunologie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Mikroskopische Untersuchungen von Alveolarepithel während der pulmonalen KryptokokkoseStart Date of Collaboration: 01/01/2015Involved persons: Alber, Gottfried; Gericke, Martin; Heyen, Laura; Piehler, Daniel; Müller, Uwe
The main focus of Gottfried Alber's university teaching is Immunology. The main lecture Immunology takes place in the 5th semester for students of veterinary medicine. Main contents of this lecture are
- Basics of Immunology
- Host defense and vaccination
- Immunopathology in domestic animals
- Clinical immunology (e.g. allergies, autoimmunity, immune deficiencies in small animals and livestock)
Seminars are integrated in this lecture. The whole staff of the Institute of Immunology contributes to the realization of these seminars. Here, groups of five students are given the opportunity to actively work on important immunological topics including the evaluation of immunological methods.
Furthermore, Prof. Alber and his staff participate in interdisciplinary focus events in the thematic areas of
- Recognition, understanding and control of infectious diseases
Lecture & Seminar "Fundamentals of Host Defense, Immunopathology and Clinical Immunology".
- Innate immunity
- Acquired humoral immunity
- Acquired cellular immunity
- Blood leukocytes (Seminar 1)
- Th1/Th2: Leishmaniasis (dog)
- Immunity against bacteria and viruses
- Antibodies: Phagocytosis and Burst (Seminar 2)
- Tuberculosis (bovine) + type IV hypersensitivity
- Allergy, autoimmunity, immune complex diseases (hypersensitivity reactions type I + II + III)
- Autoimmunity + regulatory T cells
- Immune tolerance in BVD/MD
- Tumor defense
Laboratory Animal Science
- The mouse as a laboratory animal
- Mouse models in Alzheimer research
- Alternative methods to animal experiments: Organoids and organ-on-chip as microphysiological systems
- Ethical aspects of animal experiments
- Zebrafish and Xenopus as laboratory animals
- The naked mole rat as laboratory animal
- Animal experiments in pharmacological toxicology
- The pig in animal experiments (incl. xenotransplantations)
- The dog as an experimental animal
- The horse as an experimental animal